• Vandaële E
  • PV 265
  • Mai 2006

Rapports et avis de la Commission nationale de pharmacovigilance sur les effets indésirables des avermectines et des milbémycines chez le cheval et les carnivores domestiques :
Rapport 7
Avis 7
Rapport 8
Avis 8
Rapport 9
Avis 9

1. Burrough S. Ivermectin toxicity in horses. New Zealand Vet. J., 1986 Aug ; 34 (8) : 137-138
2. Davies JA, Schwalbach LM. A study to evaluate the field efficacy of ivermectin, fenbendazole and pyrantel pamoate, with preliminary observations on the efficacy of doramectin, as anthelmintics in horses. J. South Afr. Vet. Assoc. 2000 Sep ; 71(3) : 144-7.
3. Gokbulut C, Boyacioglu M, Karademir U. Plasma pharmacokinetics and faecal excretion of ivermectin (Eqvalan paste) and doramectin (Dectomax, 1 %) following oral administration in donkeys. Res Vet Sci. 2005 Dec ; 79(3) : 233-8.
4. Gokbulut C, Nolan AM, McKellar QA.Plasma pharmacokinetics and faecal excretion of ivermectin, doramectin and moxidectin following oral administration in horses. Equine Vet J. 2001 Sep ; 33(5) : 494-8.
5. Matthee S. Anthelmintic treatment in horses: the extra-label use of products and the danger of under-dosing. J S Afr Vet Assoc. 2003 Jun ; 74(2) : 53-6.
6. Perez R, Cabezas I, Godoy C, Rubilar L, Munoz L, Arboix M, Castells G, Alvinerie M. Pharmacokinetics of doramectin and ivermectin after oral administration in horses. Vet J. 2002 Mar ; 163(2) : 161-7.

Bibliographie canine (extraite du rapport de l'Afssa)
1. Berry W.L. Spirocerca lupi esophageal granulomas in 7 dogs: resolution after treatment with doramectin. J Vet Intern Med. 2000, 14 (6); 609-12.
2. Campbell A., Chapman M., Ivermectin, in "Handbook of poisoning in dogs and cats", Blackwell Science, 2000; p 167-173.
3. Delucchi L., Castro E. Use of doramectin for treatment of notoedric mange in five cats. J Am Vet Med Assoc. 2000, 216 (2); 215-6, 193-4.
4. Frischke H., Hunt L. Suspected ivermectin toxicity in kittens. Can Vet J. 1991, 32 (4); 245.
5. Hadrick M.K., Bunch S.E., Kornegay J.N., et coll. Ivermectin toxicosis in two Australian shepherds [with additional comments from W. J. Tranquilli and J. E. Rush]. J Am Vet Med Assoc. 1995, 206 (8); 1147-1152.
6. Hopper K., Aldrich J., Haskins S.C. Ivermectin toxicity in 17 collies. J Vet Intern Med. 2002, 16 (1); 89-94.
7. Hugnet C., Bentjen S.A., Mealey K.L. Frequency of the mutant MDR1 allele associated with
multidrug sensitivity in a sample of collies from France. J Vet Pharmacol Ther. 2004, 27 (4); 227-9.
8. Lewis D.T., Merchant S.R., Neer M. Ivermectin toxicosis in a kitten. J Am Vet Med Assoc. 1994, 205 (4); 584-586.
9. Lovell R.A. Ivermectin and piperazine toxicoses in dogs and cats. Vet Clin North Am Small Anim Pract. 1990, 20 (2); 453-68.
10. Mealey K.L., Bentjen S.A., Gay J.M., et coll. Ivermectin sensitivity in collies is associated with a deletion mutation of the mdr1 gene. Pharmacogenetics. 2001, 11 (8); 727-733.
11. Mealey K.L., Bentjen S.A., Waiting D.K. Frequency of the mutant MDR1 allele associated with ivermectin sensitivity in a sample population of collies from the northwestern United States. Am J Vet Res. 2002, 63 (4); 479-81.
12. Nelson O.L., Carsten E., Bentjen S.A., et coll. Ivermectin toxicity in an Australian Shepherd dog with the MDR1 mutation associated with ivermectin sensitivity in Collies. J Vet Intern Med. 2003, 17 (3); 354-6.
13. Opmeer R.J. Hoe het Similiaprincipe van de homeopathie uitkomst bood in een noodsituatie. Een casuistiek van een ivermectine-intoxicatie in een Collie.]. [How the Similia principle of homeopathy
resolved an emergency. Case history of ivermectin poisoning in a Collie]. Tijdschr Diergeneeskd. 1997, 122 (2); 36-9; discussion 40.
14. Page S.W., Antiparasitic drugs, in "Small animal clinical pharmacology", WB Saunders, 2002; p 163-221.
15. Paul A.J., Tranquilli W.J., Ivermectin, in "Current Veterinary Therapy. Small Animal Practice." 10 ed, WB Saunders, Philadelphia, 1989; p 140-142.
16. Paul A.J., Tranquilli W.J., Seward R.L., et coll. Clinical observations in collies given ivermectin orally. Am J Vet Res. 1987, 48 (4); 684-5.
17. Plumb D.C.Veterinary Drug Handbook. 4e ed. Iowa State University Press, Ames, 2002; p 454-459.
18. Roder J.D., Stair E.L. An overview of ivermectin toxicosis. Vet Hum Toxicol. 1998, 40 (6); 369-370.
19. Roulet A., Puel O., Gesta S., et coll. MDR1-deficient genotype in Collie dogs hypersensitive to the Pglycoprotein substrate ivermectin. Eur J Pharmacol. 2003, 460 (2-3); 85-91.
20. Smith R.A., Stronski E.J., Beck B.E., et coll. Death of a Rough Collie exposed to an ivermectinbased paste. Can Vet J. 1990, 31 (3); 221.
21. Tranquilli W.J., Paul A.J., Seward R.L., et coll. Response to physostigmine administration in collie dogs exhibiting ivermectin toxicosis. J Vet Pharmacol Ther. 1987, 10 (1); 96-100.
22. Yas-Natan E., Shamir M., Kleinbart S., et coll. Doramectin toxicity in a collie. Vet Rec. 2003, 153 (23); 718-20.

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