• Michon P
  • PV 252
  • Janvier-février 2005

Effets comparatifs du paracétamol (1), des salicylés et des COX-2 inhibiteurs

Activités comparées Paracétamol (1) Salicylate COX-2 inhibiteurs
Antalgique Oui Oui Oui
Antipyrétique Oui Oui Oui
Anti-inflammatoire Non, lors d'arthrite rhumatoïde Oui Oui
Inhibitrice d'agrégation plaquettaire in vitro Non Non Non
Promotrice de saignements gastro-intestinaux Non Non Non
Négative sur l'excrétion rénale de Na+ Non ? Oui


Légende : D'après [8].

Références bibliographiques

1 - Ayoub SS, Botting RM, Goorha S et coll. Acetaminophen-induced hypothermia in mice is mediated by a prostaglandin endoperoxide synthase 1 gene-derived protein. Proc. Natl. Acad. Sci. USA. 2004;101(30):11165-11169.
2 - Botting RM. Mechanism of action of acetaminophen: is there a cyclooxygenase 3? Clin. Infect. Dis. 2000;31 Suppl 5:S202-210.
3 - Botting R. COX-1 and COX-3 inhibitors. Thromb. Res. 2003;110(5-6):269-272.
4 - Chandrasekharan NV, Dai H, Roos KL et coll. COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression. Proc. Natl. Acad. Sci. USA. 2002;99(21):13926-13931.
5 - Chen C, Bazan NG. Acetaminophen modifies hippocampal synaptic plasticity via a presynaptic 5-HT2 receptor. Neuroreport. 2003;14(5):743-747.
6 - Ehrlich K, Sicking C, Respondek M et coll. Interaction of cyclooxygenase isoenzymes, nitric oxide, and afferent neurons in gastric mucosal defense in rats.J. Pharmacol. Exp. Ther. 2004;308(1):277-83.
7 - Flower RJ, Vane JR. 1972, Inhibition of prostaglandin synthetase in brain explains the anti-pyretic activity of paracetamol (4-acetamidophenol). Nature (London). 1972;240(5381):410-411.
8 - Graham GG, Scott KF. Mechanisms of action of paracetamol and related analgesics. Inflammopharmacology. 2003;11(4):401-413.
9 - Gryglewski RJ, Swies J, Uracz W et coll. Mechanisms of angiotensin-converting enzyme inhibitor induced thrombolysis in Wistar rats. Thromb. Res. 2003;110(5-6):323-329.
10 - Kis B, Snipes JA, Isse T et coll. Putative cyclooxygenase-3 expression in rat brain cells. J. Cereb. Blood Flow Metab. 2003;23(11):1287-292.
11 - Kis B, Snipes A, Bari F et coll. Regional distribution of cyclooxygenase-3 mRNA in the rat central nervous system. Brain Res. Mol. Brain Res. 2004 Jul 5;126(1):78-80.
12 - Ramsay RG, Ciznadija D, Vanevski M et coll. Transcriptional regulation of cyclo-oxygenase expression: three pillars of control. Int. J. Immunopathol. Pharmacol. 2003;16(2 Suppl):59-67.
13 - Schwab JM, Schluesener HJ, Laufer S. COX-3: just another COX or the solitary elusive target of paracetamol? Lancet. 2003;361(9362):981-982.
14 - Schwab JM, Schluesener HJ, Meyermann R et coll. COX-3 the enzyme and the concept: steps towards highly specialized pathways and precision therapeutics? Prostaglandins Leukot. Essent. Fatty Acids. 2003;69(5):339-343.
15 - Schwab JM, Beiter T, Linder JU. COX-3--a virtual pain target in humans? FASEB J. 2003;17(15):2174-2175.
16 - Shaftel SS, Olschowka JA, Hurley SD et coll. COX-3: a splice variant of cyclooxygenase-1 in mouse neural tissue and cells. Brain Res. Mol. Brain Res. 2003;119(2):213-215.
17 - Simmons DL. Variants of cyclooxygenase-1 and their roles in medicine. Thromb. Res. 2003;110(5-6):265-268.
18 - Warner TD, Mitchell JA. Cyclooxygenase-3 (COX-3): filling in the gaps toward a COX continuum? Proc. Natl. Acad. Sci. USA. 2002;99(21):13371-13373.
19 - Willoughby DA, Moore AR, Colville-Nash PR. COX-1, COX-2, and COX-3 and the future treatment of chronic inflammatory disease. Lancet. 2000;355(9204):646-648.


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